What is anabolic resistance

Anabolic resistance refers to the reduced ability of muscle to grow and repair in response to anabolic stimuli, such as dietary protein and exercise.

Anabolic resistance refers to the reduced ability of muscle to grow and repair in response to anabolic stimuli, such as dietary protein and exercise. This condition is primarily associated with aging but can also be influenced by factors like obesity, inflammation, and a sedentary lifestyle. 

As people age, their muscles become less sensitive to the stimulatory effects of protein intake and physical activity, leading to a decrease in muscle protein synthesis. This reduced sensitivity contributes to muscle atrophy and decreased physical performance, commonly seen in conditions like sarcopenia. 

Additionally, insulin resistance, which often increases with age, can exacerbate anabolic resistance by impairing muscle protein metabolism. 

Strategies to mitigate anabolic resistance include maintaining a physically active lifestyle, incorporating resistance training, and ensuring adequate protein intake, particularly high-quality protein rich in essential amino acids like leucine. 

These interventions can help preserve muscle mass and function, improving overall health and quality of life in older adults. 

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